The Maserati 250F was in '2.5 litre' Formula One racing between January 1954 and November 1960. Twenty-six examples were made.

The 250F principally used the SSG 220 bhp (@ 7400 rpm) 2.5-litre Maserati A6 straight-six engine, ribbed 13.4" drum brakes, wishbone independent front suspension, a De Dion tube axle, Borrani 16" & 17" wheels and Pirelli Stella Bianca tyres. It was built by Gioacchino Colombo, Vittorio Bellentani and Alberto Massimino; the tubular work was by Valerio Colotti.